The Amazing Spider-Man is an American comic book series published by Marvel Comics, featuring the fictional superhero Spider-Man as its main protagonist. Being in the mainstream continuity of the franchise, it began publication in 1963 as a bimonthly periodical (as Amazing Fantasy had been) and was published continuously, with a brief interruption in 1995, until its second volume with a new numbering order in 1999. In 2003 the series reverted to the numbering order of the first volume. The title has occasionally been published biweekly, and was published three times a month from 2008 to 2010.

After DC Comics' relaunch of Action Comics and Detective Comics with new No. 1 issues in 2011, it had been the highest-numbered American comic still in circulation until it was cancelled. The title ended its 50-year run as a continuously published comic with the landmark issue #700 in December 2012. It was replaced by The Superior Spider-Man as part of the Marvel NOW! relaunch of Marvel's comic lines.

Volume 3 of The Amazing Spider-Man was published in April 2014, following the conclusion of The Superior Spider-Man story arc. In late 2015, the series was relaunched with a 4th volume, following the 2015 Secret Wars event. The 5th and current volume began in 2018, as part of Marvel's Fresh Start series of comic relaunches.