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Answer» What is Lower East Side mean? The Lower East Side, sometimes abbreviated as LES and sometimes referred to as Loisaida, is a neighborhood in the southeastern part of the New York City borough of Manhattan, roughly between the Bowery and the East River from Canal to Houston streets. Traditionally an immigrant, working-class neighborhood, it began rapid gentrification in the mid-2000s, prompting the National Trust for Historic Preservation to place the neighborhood on their list of America's Most Endangered Places. The Lower East Side is part of Manhattan Community District 3, and its primary ZIP Code is 10002. It is patrolled by the 7th Precinct of the New York City Police Department. reference
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