The Mesquite Independent School District is a school district in Mesquite, Texas (USA) (incorporating most of Mesquite and portions of Balch Springs, Dallas, Garland, and Seagoville, as well as formerly serving all high school students of Sunnyvale) which follows the standard definition of an independent school district.

The district contains over 35,000 students. There are five main high schools, Three of which are AAAAAA (or 6A, the highest in a system of Texas school size classification). As of July 1, 2015, the superintendent is Dr. David Vroonland.

All houses and residential areas in Mesquite ISD are each assigned to an elementary school (Pre-K-5 or K-5), a middle school (6-8), and a high school (9-12).

In addition, the MISD operates two high school football facilities for its high schools, Memorial Stadium near West Mesquite High School (which is the largest high-school football stadium in Texas, seating nearly 20,000 ) and E. H. Hanby Stadium, which is located adjacent to Mesquite High School.

In 2009, the school district was rated "Recognized" by the Texas Education Agency.