The Naval Safety Center is a U.S. Navy organization.

In May 1968, the Naval Aviation Safety Center and the Submarine Safety Center, located in New London, Connecticut, merged to become the Naval Safety Center (NSC). Programs involving surface ships and shore activities were added to form the nucleus for all safety programs within the Navy. In 1986, system safety was added as a program, and the position of a Marine Corps deputy commander was established to administer and represent Marine Corps safety issues.

Today, the Naval Safety Center is organized into four directorates: aviation, afloat, shore, and operational risk management/expeditionary warfare. Six departments and five special staff divisions provide support to the core operations of the command. The Naval School of Aviation Safety in Pensacola, Florida, is also a NAVSAFECEN detachment consisting of civilian and military staff, which includes Marine Corps personnel. As an Echelon II command, NAVSAFECEN provides oversight of its single Echelon III command, the Naval Safety and Environmental Training Center in Norfolk, Virginia.

One of the NSC's subsections is Navy Occupational Safety & Health (NAVOSH). NAVOSH is responsible for safety practices within the Navy. NAVOSH provides safety assistance and advice to the CNO, CMC, and the Deputy Assistant Secretary of the Navy for Safety with the aim of enhancing the war-fighting capability of the Navy and Marine Corps, preserve resources, and improve combat readiness by preventing mishaps and saving lives.