Answer» What is Nukus mean? Nukus (Uzbek: Nukus, Нукус; Karakalpak: Nókis, Нөкис; Kazakh: Нүкіс, romanized: Nükıs) is the sixth-largest city in Uzbekistan and the capital of the autonomous Republic of Karakalpakstan. The population of Nukus as of April 1, 2021 was approximately 325,100. The Amu Darya river passes west of the town. The city is best known for its world-class Nukus Museum of Art. reference
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