Space Ghost Coast to Coast is an American adult animated parody talk show created by Mike Lazzo and hosted by a re-imagined version of the 1960s Hanna-Barbera cartoon character Space Ghost. In contrast to the original 1960s series, Space Ghost, which aired as a standard Hanna-Barbera Saturday-morning superhero cartoon, Space Ghost Coast to Coast is a reboot of the series intended for teens and adults, reinterpreted as a surreal spoof talk show and animated using the original series' artwork. For its first two seasons, the series is presented as a serious talk show with subdued jokes, but later seasons rely more on surrealism and non-sequitur humor.

Space Ghost Coast to Coast is one of the early original series fully produced by Cartoon Network. It premiered on April 15, 1994, and originally ended on December 17, 1999. The series was revived on May 7, 2001, and was moved to the then-new Adult Swim late-night programming block on September 2, where new episodes premiered until April 12, 2004. Two final seasons were released exclusively on GameTap from 2006 to 2008. Over 11 seasons, 108 episodes aired. The series helped to launch the careers of animators Adam Reed, Matt Thompson, Andy Merrill, Jim Fortier, Pete Smith, Michael Ouweleen, Eric Richter, Dave Willis, and Matt Maiellaro.

Two spinoff series, Cartoon Planet and The Brak Show, are based on Space Ghost: Coast to Coast. The series has also inspired or influenced other animated series for Adult Swim, including Sealab 2021; Aqua Teen Hunger Force; and Harvey Birdman, Attorney at Law.