| Student Information Record System | Academic & Science |
| Social Issue Research Services | Academic & Science |
| School Improvement Research Series | Academic & Science |
| Student Information Reporting System | Academic & Science |
| Student Instructional Rating Survey | Academic & Science |
| Student Information Repository System | Academic & Science |
| Schizophrenia International Research Society | Academic & Science |
| Social Issues Research Service | Business |
| Social Issues Resource Series | Community |
| Scout International Relief Service | Community |
| Structure Inventory Records System | Computing |
| Stores Inventory Request System | Computing |
| Social Issues Reference Service | General |
| Social Issue Resource Series | General |
| Solar Infrared Radiation Station | General |
| Securities Information Retrieval Service | General |
| Stennis Image Retrieval System | General |
| Sons In Retirement SIR | General |
| Southern Indiana Resource Solutions | General |
| Serials Issues Resources Series | General |
| Social Issues Resources Series | General |
| Smart Indicators for Reflection Support | General |
| Salary Information Retrieval System | General |
| Strategic Industry Reward Solutions | General |
| Septic Inflammatory Response System | General |
| Side Impact Restraint System | General |
| Scalable Internet Resource Service | Internet |
| Safesite Internet Records System | Internet |
| Systemic Inflammatory Response Syndrome | Medical |
| Systemic Immune Response Syndrome | Medical |
| Shelbyville Industrial Rail Service | Regional |
