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The Strategic Advisory Group of Experts (SAGE) is the principal advisory group to World Health Organization (WHO) for vaccines and immunization. Established in 1999 through the merging of two previous committees, notably the Scientific Advisory Group of Experts (which served the Program for Vaccine Development) and the Global Advisory Group (which served the EPI program) by Director-General of the WHO Gro Harlem Brundtland. It is charged with advising WHO on overall global policies and strategies, ranging from vaccines and biotechnology, research and development, to delivery of immunization and its linkages with other health interventions. SAGE is concerned not just with childhood vaccines and immunization, but all vaccine-preventable diseases. SAGE provide global recommendations on immunization policy and such recommendations will be further translated by advisory committee at the country level.

The Semi-Automatic Ground Environment (SAGE) was a system of large computers and associated networking equipment that coordinated data from many radar sites and processed it to produce a single unified image of the airspace over a wide area. SAGE directed and controlled the NORAD response to a possible Soviet air attack, operating in this role from the late 1950s into the 1980s. Its enormous computers and huge displays remain a part of cold war lore, and after decommisioning were common prop in movies such as Dr. Strangelove and Colossus, and on science fiction TV series such as The Time Tunnel.

The processing power behind SAGE was supplied by the largest discrete component-based computer ever built, the IBM-manufactured AN/FSQ-7. Each SAGE Direction Center (DC) housed an FSQ-7 which occupied an entire floor, approximately 22,000 square feet (2,000 m2) not including supporting equipment. The FSQ-7 was actually two computers, "A" side and "B" side. Computer processing was switched from "A" side to "B" side on a regular basis, allowing maintenance on the unused side. Information was fed to the DCs from a network of radar stations as well as readiness information from various defense sites. The computers, based on the raw radar data, developed "tracks" for the reported targets, and automatically calculated which defenses were within range. Operators used light guns to select targets on-screen for further information, select one of the available defenses, and issue commands to attack. These commands would then be automatically sent to the defense site via teleprinter.

Connecting the various sites was an enormous network of telephones, modems and teleprinters. Later additions to the system allowed SAGE's tracking data to be sent directly to CIM-10 Bomarc missiles and some of the US Air Force's interceptor aircraft in-flight, directly updating their autopilots to maintain an intercept course without operator intervention. Each DC also forwarded data to a Combat Center (CC) for "supervision of the several sectors within the division" ("each combat center [had] the capability to coordinate defense for the whole nation").: 51 

SAGE became operational in the late 1950s and early 1960s at a combined cost of billions of dollars. It was noted that the deployment cost more than the Manhattan Project—which it was, in a way, defending against. Throughout its development, there were continual concerns about its real ability to deal with large attacks, and the Operation Skyshield tests showed that only about one-fourth of enemy bombers would have been intercepted. Nevertheless, SAGE was the backbone of NORAD's air defense system into the 1980s, by which time the tube-based FSQ-7's were increasingly costly to maintain and completely outdated. Today the same command and control task is carried out by microcomputers, based on the same basic underlying data.

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The Scientific Advisory Group for Emergencies (SAGE) is a British Government body that advises central government in emergencies. It is usually chaired by the United Kingdom's Chief Scientific Adviser, currently Sir Patrick Vallance. Specialists from academia and industry, along with experts from within government make up the participation, which will vary depending on the emergency. SAGE gained public prominence for its role in the 2020 COVID-19 pandemic in the United Kingdom.

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