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The Savannah River National Laboratory (SRNL) is a multi-program national laboratory for the U.S. Department of Energy’s (DOE) Office of Environmental Management. SRNL is located at the Savannah River Site (SRS) near Jackson, South Carolina. It was founded in 1951, as the Savannah River Laboratory. It was certified as a national laboratory on May 7, 2004.

SRNL research topics include environmental remediation, technologies for the hydrogen economy, handling of hazardous materials and technologies for prevention of nuclear proliferation. It has specific experience in vitrification of nuclear waste and hydrogen storage initially developed to support production of tritium and plutonium at the Savannah River Site during the Cold War. SRNL is a founding member of the South Carolina Hydrogen & Fuel Cell Alliance (SCHFCA).

SRNL employs 980 people and has an annual programmatic budget of 249 million U.S. Dollars (2017).

SRNL has been operated by Savannah River Nuclear Solutions, LLC for the U.S. Department of Energy since 2008. The LLC is a partnership between Fluor Corporation, Newport News Nuclear, Inc. (a subsidiary of Huntington Ingalls Industries) and Honeywell International.

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The Hamilton Rating Scale for Depression (HRSD), also called the Hamilton Depression Rating Scale (HDRS), sometimes also abbreviated as HAM-D, is a multiple-item questionnaire used to provide an indication of depression, and as a guide to evaluate recovery. Max Hamilton originally published the scale in 1960 and revised it in 1966, 1967, 1969, and 1980. The questionnaire is designed for adults and is used to rate the severity of their depression by probing mood, feelings of guilt, suicide ideation, insomnia, agitation or retardation, anxiety, weight loss, and somatic symptoms.

The HRSD has been criticized for use in clinical practice as it places more emphasis on insomnia than on feelings of hopelessness, self-destructive thoughts, suicidal cognitions and actions. An antidepressant may show statistical efficacy even when thoughts of suicide increase but sleep is improved, or for that matter, an antidepressant that as a side effect increase sexual and gastrointestinal symptom ratings may register as being less effective in treating the depression itself than it actually is. Hamilton maintained that his scale should not be used as a diagnostic instrument.

The original 1960 version contained 17 items (HDRS-17), but four other questions not added to the total score were used to provide additional clinical information. Each item on the questionnaire is scored on a 3 or 5 point scale, depending on the item, and the total score is compared to the corresponding descriptor. Assessment time is about 20 minutes.

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