Explore topic-wise InterviewSolutions in Medical.

INFO: Full form for AR is Apical Rate in Medical category
AR also has other full forms in other categories mentioned below.

Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).

Sustained-release dosage forms are dosage forms designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects. This can be achieved through a variety of formulations, including liposomes and drug-polymer conjugates (an example being hydrogels). Sustained release's definition is more akin to a "controlled release" rather than "sustained".

Extended-release dosage consists of either sustained-release (SR) or controlled-release (CR) dosage. SR maintains drug release over a sustained period but not at a constant rate. CR maintains drug release over a sustained period at a nearly constant rate.

Sometimes these and other terms are treated as synonyms, but the United States Food and Drug Administration has in fact defined most of these as different concepts. Sometimes the term "depot tablet" is used by non-native speakers, but this is not found in any English dictionaries and is a literal translation of the term used in Swedish and some other languages.

Modified-release dosage and its variants are mechanisms used in tablets (pills) and capsules to dissolve a drug over time in order to be released slower and steadier into the bloodstream while having the advantage of being taken at less frequent intervals than immediate-release (IR) formulations of the same drug. For example, extended-release morphine enables people with chronic pain to only take one or two tablets per day.

Most commonly it refers to time dependent release in oral dose formulations. Timed release has several distinct variants such assustained release where prolonged release is intended, pulse release, delayed release (e.g. to target different regions of the GI tract) etc. A distinction of controlled release is that not only it prolongs action but it attempts to maintain drug levels within the therapeutic window to avoid potentially hazardous peaks in drug concentration following ingestion or injection and to maximize therapeutic efficiency.

In addition to pills, the mechanism can also apply to capsules and injectable drug carriers (that often have an additional release function), forms of controlled release medicines include gels, implants and devices (e.g. the vaginal ring and contraceptive implant) and transdermal patches.

Examples for cosmetic, personal care, and food science applications often centre on odour or flavour release.

The release technology scientific and industrial community is represented by the Controlled Release Society (CRS). The CRS is the worldwide society for delivery science and technologies. CRS serves more than 1,600 members from more than 50 countries. Two-thirds of CRS membership is represented by industry and one-third represents academia and government. CRS is affiliated with the Journal of Controlled Release and Drug Delivery and Translational Research scientific journals.

INFO: Full form for SR is Slime Resistant in Medical category
SR also has other full forms in other categories mentioned below.

INFO: Full form for SR is Severely Restricted in Medical category
SR also has other full forms in other categories mentioned below.

Systematic reviews are a type of review that uses repeatable analytical methods to collect secondary data and analyse it. Systematic reviews are a type of evidence synthesis which formulate research questions that are broad or narrow in scope, and identify and synthesize data that directly relate to the systematic review question. While some people might associate 'systematic review' with 'meta-analysis', there are multiple kinds of review which can be defined as 'systematic' which do not involve a meta-analysis. Some systematic reviews critically appraise research studies, and synthesize findings qualitatively or quantitatively. Systematic reviews are often designed to provide an exhaustive summary of current evidence relevant to a research question. For example, systematic reviews of randomized controlled trials are an important way of informing evidence-based medicine, and a review of existing studies is often quicker and cheaper than embarking on a new study.

While systematic reviews are often applied in the biomedical or healthcare context, they can be used in other areas where an assessment of a precisely defined subject would be helpful. Systematic reviews may examine clinical tests, public health interventions, environmental interventions, social interventions, adverse effects, qualitative evidence syntheses, methodological reviews, policy reviews, and economic evaluations.

An understanding of systematic reviews and how to implement them in practice is highly recommended for professionals involved in the delivery of health care, public health and public policy.

INFO: Full form for SR is Sethoxydim Resistant in Medical category
SR also has other full forms in other categories mentioned below.

Avalanche Studios Group is a Swedish video game developer and publisher based in Stockholm. It is a parent company that includes Avalanche Studios, Expansive Worlds, and Systemic Reaction. Founded by Linus Blomberg and Christofer Sundberg in March 2003, Avalanche Studios focuses on developing open world projects and bases them on their proprietary Apex game engine (formerly known as Avalanche Engine). The company is best known for developing the Just Cause game series.

Formed after the collapse of Rock Solid Games, the studio gained early success with the first Just Cause title. The team then began Just Cause 2's development, but the company suffered from financial problems due to the cancellations of two contracted projects. Despite missing the release window twice, Just Cause 2 was both a critical and financial success for Avalanche Studios. The company then opened a studio in New York City to work on Just Cause 3, while the Stockholm team began working on Mad Max in collaboration with Warner Bros. Interactive Entertainment. The company announced two titles in 2017, Rage 2 with id Software and a self-published title named Generation Zero. Nordisk Film also acquired the company in the same year.

A casual gaming subsidiary, Expansive Worlds, was established in March 2010 to work on theHunter series. The company aims to begin self-publishing new original intellectual properties in the future. In addition to the offices in Stockholm and New York City, the company opened a second Swedish office in Malmö in May 2018 and an office in Liverpool in June 2020.