Explore topic-wise InterviewSolutions in Medical.

INFO: Full form for FMR is Family Medical Records in Medical category
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INFO: Full form for FIM is Functional Independence Measuring in Medical category
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INFO: Full form for FIM is Functional Improvement Measurement in Medical category
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INFO: Full form for DMRD is Diploma Medical Radio diagnosis in Medical category
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INFO: Full form for DMRD is Diploma in Medical Radiology Diagnosis in Medical category
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Brighton and Sussex Medical School (BSMS) is a medical school formed as a partnership of the University of Brighton and the University of Sussex. Like other UK medical schools it is based on the principles and standards of 'Tomorrow's Doctors', an initiative by the General Medical Council outlining the role of British practitioners. Since opening in 2003, BSMShas produced more than 1,500 new doctors who now work across the UK.

INFO: Full form for GDM is Gestational diabtes mellitus in Medical category
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INFO: Full form for GDM is Gestational Diabetes Mellitus in Medical category
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INFO: Full form for MAF is Macrophage Activating Factor in Medical category
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INFO: Full form for MAF is Management Accountancy Framework in Medical category
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INFO: Full form for MAF is Maximum Aerobic Function in Medical category
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INFO: Full form for MAF is Multidimensional Assessment of Fatigue in Medical category
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Cell polarity is a fundamental feature of many types of cells. Epithelial cells are one example of a polarized cell type, featuring distinct 'apical', 'lateral' and 'basal' plasma membrane domains. Epithelial cells connect to one another via their lateral membranes to form epithelial sheets that line cavities and surfaces throughout the animal body. Each plasma membrane domain has a distinct protein composition, giving them distinct properties and allowing directional transport of molecules across the epithelial sheet. How epithelial cells generate and maintain polarity remains unclear, but certain molecules have been found to play a key role.

A variety of molecules are located at the apical membrane, but only a few key molecules act as determinants that are required to maintain the identity of the apical membrane and, thus, epithelial polarity. These molecules are the proteins Cdc42, atypical protein kinase C (aPKC), Par6, Par3/Bazooka/ASIP. Crumbs, "Stardust" and protein at tight junctions (PATJ). These molecules appear to form two distinct complexes: an aPKC-Par3-Par6 "aPKC" (or "Par") complex that also interacts with Cdc42; and a Crumbs-Stardust-PATJ "Crumbs" complex. Of these two complexes, the aPKC complex is the most important for epithelial polarity, being required even when the Crumbs complex is not. Crumbs is the only transmembrane protein in this list and the Crumbs complex serves as an apical cue to keep the aPKC complex apical during complex cellular shape changes.

INFO: Full form for BLM is Bimolecular Lipid Membrane in Medical category
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INFO: Full form for BLM is Bilayer Lipid Membrane in Medical category
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INFO: Full form for BLM is Black Lipid Mmbrane in Medical category
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Bleomycin is a medication used to treat cancer. This includes Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, ovarian cancer, and cervical cancer among others. Typically used with other cancer medications, it can be given intravenously, by injection into a muscle or under the skin. It may also be administered inside the chest to help prevent the recurrence of a fluid around the lung due to cancer; however talc is better for this.

Common side effects include fever, weight loss, vomiting, and rash. A severe type of anaphylaxis may occur. It may also cause inflammation of the lungs that can result in lung scarring. Chest X-rays every couple of weeks are recommended to check for this. Bleomycin may cause harm to the baby if used during pregnancy. It is believed to primarily work by preventing the making of DNA.

Bleomycin was discovered in 1962. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. It is made by the bacterium Streptomyces verticillus.

INFO: Full form for CMR is Cardiac MRI Research in Medical category
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INFO: Full form for CMR is Comprehensive Medication Review in Medical category
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